Amniocentesis and fetal lung development

Mid-trimester amniocentesis fetal loss rate.

OBJECTIVE To determine the postprocedure loss rate for mid-trimester genetic amniocentesis. OUTCOME Reduction of benign biopsy rates. BENEFITS To provide better advice for women about the risks and benefits of mid-trimester genetic amniocentesis, and to ensure that women are given sufficient information/counselling to make a decision about screening. SUMMARY STATEMENT The risk of postproc...

Fetal loss rates after mid-trimester amniocentesis

Objective: Amniocentesis is an invasive cytogenic test traditionally associated with a 1/200 procedure–related pregnancy loss rate. Recent studies have questioned the validity of the traditionally stated rate. The purpose of this study was to document the results of second-trimester genetic amniocentesis performed at our perinatalogy clinic. Study Design: A retrospective review of all the amnio...

Clostridium perfringens Sepsis and Fetal Demise after Genetic Amniocentesis

Clostridium perfringens is a rare cause of intrauterine infection. There have been five case reports concerning infection associated with invasive procedures. We report a woman who underwent a genetic amniocentesis due to her history of chronic granulomatous disease. She presented to the hospital ∼38 hours after the amniocentesis complaining of fever and chills. Due to acute decompensation, she...

Development of a diploid cellline from fetal calf lung for virus vaccine production

MicroRNA-127 modulates fetal lung development.

MicroRNAs (miRNAs) are small endogenous RNAs and are widely regarded as one of the most important regulators of gene expression in both plants and animals. To define the roles of miRNAs in fetal lung development, we profiled the miRNA expression pattern during lung development with a miRNA microarray. We identified 21 miRNAs that showed significant changes in expression during lung development....